Located on the western side of the country, Cayo borders Guatemala and is geographically Belize’s largest district, with a majestic 880,000 acres of protected land in the form of nature reserves and national parks, this district is truly a nature-lover’s dream.. The lively towns of San Ignacio and Santa Elena are the travelers most popular stops. Also, the quiet border town of Benque Viejo del Carmen is home to many Mayan settlements as well.